Impaired L-type Ca2+ channel function in the dystrophic heart
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چکیده
منابع مشابه
L-type Ca2+ channel function in the avian embryonic heart after cardiac neural crest ablation.
In avian and mammalian embryos, surgical ablation or severely reduced migration of the cardiac neural crest leads to a failure of outflow tract septation known as persistent truncus arteriosus (PTA) and leads to embryo lethality due partly to impaired excitation-contraction coupling stemming primarily from a reduction in the L-type Ca(2+) current (I(Ca),(L)). Decreased I(Ca,L) occurs without a ...
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During the cardiac action potential, Ca(2+) entry through dyhidropyridine receptor L-type Ca(2+) channels (DHPRs) activates ryanodine receptors (RyRs) Ca(2+)-release channels, resulting in massive Ca(2+) mobilization from the sarcoplasmic reticulum (SR). This global Ca(2+) release arises from spatiotemporal summation of many localized elementary Ca(2+)-release events, Ca(2+) sparks. We tested w...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2012
ISSN: 2050-6511
DOI: 10.1186/2050-6511-13-s1-a41